Overview:
- Marmosets bridge the rodent to human translational gap
- Overcome limitations of other model organisms by exhibiting primate-specific aging and dementia phenotypes
- Gain translatable knowledge through simultaneous assessment of genetic, molecular, functional, behavioral, and pathological phenotypes
- Identify emerging phenotypes that precede frank neuropathy through gene-edited models with genetic risk for EOAD and LOAD
Goals:
Establish the marmoset as the first primate-specific model of AD
- Reveal the earliest cellular and molecular events of AD processes and allow charting AD progression from its inception.
Develop marmoset models of early-onset AD and late-onset AD
- Investigate the underlying cellular and molecular root causes of the pathogenesis and progression of AD.
- Assess genetic, molecular, functional, behavioral, and pathological phenotypes simultaneously in marmosets.
Provide translatable knowledge of the origins and progression of AD in human populations
MARMO-AD is a collaboration between the following organizations: